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Local and Systemic Responses to SARS-CoV-2 Infection in Children and Adults

Worlock, K.; Yoshida, M.; Lindeboom, R. G. H.; Huang, N.; Butler, C. R.; Kumasaka, N.; Conde, C. D.; Mamanova, L.; Bolt, L.; Richardson, L.; Polanski, K.; Madissoon, E.; Barnes, J. L.; Allen-Hyttinen, J.; Kilich, E.; Jones, B. C.; de Wilton, A.; Wilbrey-Clark, A.; Pett, J.; Prigmore, E.; Yung, H.; Mehta, P.; Saleh, A.; Saigal, A.; Cohen, J.; Chu, V.; Reuschl, A.; Argento, C.; Wunderink, R. G.; Smith, S. B.; Poor, T. A.; Gao, C. A.; Dematte, J. E.; Reynolds, G.; Haniffa, M.; Bowyer, G. S.; Coates, M.; Clatworthy, M. R.; Calero-Nieto, J.; Gottgens, B.; O'Callaghan, C.; Sebire, N. J.; Jolly, C.; de Coppi, P.; Smith, C. M.; Misharin, A. V.; Janes, S. M.; Meyer, K. B.; Nikoli, M. Z.; Investigators, Nu Script Study.

American Journal of Respiratory and Critical Care Medicine ; 205:2, 2022.

Article in English | English Web of Science | ID: covidwho-1881031

The local and systemic response to SARS-CoV-2 infection in children and adults

Worlock, K. B.; Yoshida, M.; Lindeboom, R. G. H.; Huang, N.; Butler, C. R.; Kumasaka, N.; Conde, C. Dominguez, Mamanova, L.; Bolt, L.; Richardson, L.; Polanski, K.; Madissoon, E.; Barnes, J. L.; Allen-Hyttinen, J.; Kilich, E.; Jones, B. C.; de Wilton, A.; Wilbrey-Clark, A.; Sungnak, W.; Pett, J. P.; Prigmore, E.; Yung, H.; Mehta, P.; Saleh, A.; Saigal, A.; Chu, V.; Cohen, J. M.; Cane, C.; Iordanidou, A.; Shibuya, S.; Reuschl, A. K.; Argento, A. C.; Wunderink, R. G.; Smith, S. B.; Poor, T. A.; Gao, C. A.; Dematte, J. E.; Reynolds, G.; Haniffa, M.; Bowyer, G. S.; Coates, M.; Clatworthy, M. R.; Calero-Nieto, F. J.; Göttgens, B.; O’Callaghan, C.; Sebire, N. J.; Jolly, C.; de Coppi, P.; Smith, C. M.; Misharin, A. V.; Janes, S. M.; Teichmann, S. A.; Meyer, K. B.; Nikolić, M. Z..

Thorax ; 76(Suppl 2):A1, 2021.

Article in English | ProQuest Central | ID: covidwho-1507054

ABSTRACT

T1 Figure 1ConclusionsOverall, this largest paediatric single cell COVID-19 study to date showed significant differences in response to SARS-CoV-2 between children and adults, reflecting the changes of the immune landscape over developmental time, which in children are dominated by naïve and innate responses.

ABSTRACT

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